Trimethylglycine (TMG), also known as betaine anhydrous, is an amino acid that supports the body's methylation processes.

Methylation is a fundamental biochemical process in which one carbon atom and three hydrogen atoms (CH3) are transferred from one molecule to another.

Methylation is responsible for numerous important bodily functions, such as cell division, cellular energy production, clearing histamine, metabolism, DNA expression (epigenetics), forming neurotransmitters and producing free radical-scavenging antioxidants.

Our bodies contain a "methyl pool" of CH3 that is available whenever needed. As long as we have enough methyl groups stored in the pool, methylation typically is not a problem. However, there are a couple of things that may contribute to the depletion of the body's methyl pool.

• MTHFR Variants - Methylenetetrahydrofolate reductase (MTHFR) is a gene with common mutations that can interfere with the methylation process, causing high levels of homocysteine (a known risk factor in heart health conditions) in the blood and low folate levels. Up to 40% of the population may have one or both genetic mutations.
• Aging and Epigenetics - Methylation of DNA plays a crucial role in epigenetics, switching different sequences of your genetic material on and off as needed. The body's methylation ability and subsequent DNA expression are known to decline with age. Anti-aging researchers think these changes in DNA expression may be a contributing factor to many age-related diseases.
• NMN Supplementation and Methylation Support. When taken as a supplement, NMN may require the use of methyl groups to help facilitate the conversion of NAD+ in your cells, thereby activating sirtuin genes and promoting longevity. Although there is currently no evidence suggesting NMN's natural methylation process depletes the methyl pool, many top anti-aging experts suggest that safeguarding against methyl depletion may be a wise proactive step to augment your NMN intake.

*This is a statement of nutritional support. This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any diseases. Individual results may vary.